Iontophoresis as a treatment for primary hyperhidrosis: a quasi-experimental study

Abstract

Primary hyperhidrosis is a chronic condition characterized by excessive sweating beyond what is necessary for thermoregulation, often leading to significant physical discomfort and emotional distress. Iontophoresis has emerged as a non-invasive treatment option for managing primary hyperhidrosis. This experimental study aimed to investigate the effectiveness of iontophoresis in reducing sweat production and improving the quality of life in individuals with primary hyperhidrosis. A total of 111 responses what was founded from online survey, pestering and other media. 37 participants showed their interest to take the treatment of primary hyperhidrosis. From them 28 participants completed the full dose of treatment. Diagnosis was done in two centers by two Physiotherapy professional who were aware about the iontophoresis, it’s application and precision. Application of intervention was also done under their supervision. One center was BHPI, CRP and another center was DCPT. The severity of hyperhidrosis was assessed using the Hyperhidrosis Disease Severity Scale (HDSS), Minors Starch-iodine test and Hyperhidrosis Quality of Life Index (HidroQoL©) at before the intervention and after 9-10 session. The iontophoresis treatment involved the application of a mild electrical current to the affected areas, such as the palms, soles, or axillae, using specialized iontophoresis devices. This study was done only for palmer hyperhidrosis. Participants received treatment sessions three times per week for three weeks. Results demonstrated a significant reduction in HDSS scores after 9-10 session (p < 0.05). After complete the sessions, all of the participants reported a decrease in HDSS score by two or more categories, indicating a clinically meaningful improvement in hyperhidrosis severity. Furthermore, participants reported a considerable decrease in sweat production, as measured by Minors Starch-iodine test, from baseline to 9-10 sessions (p < 0.001). The treatment was well-tolerated, with no severe adverse events reported. The most commonly reported side effect was mild skin irritation in some participants. However, the irritation was transient and did not deter participants from continuing with the treatment. In addition to reducing hyperhidrosis severity, the iontophoresis treatment had a positive impact on participants' quality of life. The Hyperhidrosis Quality of Life Index (HidroQoL©) improved significantly among the participants after 9-10 sessions (p < 0.01), indicating a substantial enhancement in overall well-being and psychosocial functioning. Keywords: Hyperhidrosis, Iontophoresis. Word Count: 10440